KMWorld cited CCC for its innovative efforts in “integrating, accessing, and sharing information through licensing, content software, and professional services [and] designing and delivering innovative information solutions that power decision making.”

Other companies on the 2023 KMWorld list include Accenture, Adobe, AWS, Deloitte, Google, IBM, Microsoft, Oracle, and Salesforce.

“Customer conversations about content users’ experiences continue to guide us as we develop solutions to transform information into insight,” said Tracey Armstrong, President and CEO, CCC. “As we look forward, CCC will continue to invest in accelerating access to content, enhancing data quality, and supporting new workflows that rely increasingly on machine learning and artificial intelligence.”

According to KMWorld, “The increasing power of augmented and artificial intelligence, machine learning, natural language processing (NLP), semantic layering, vectorization, knowledge graphs, cloud computing and storage, chatbots, text analytics, and a host of others has revolutionized many aspects of KM.”

CCC’s award-winning RightFind Suite is a set of integrated, flexible software solutions that enable professionals at R&D-intensive companies to search, discover, access, read, share, organize, collaborate on, and analyze content to generate data-driven insights that give their organizations a competitive edge. Seven out of the top ten life science companies on the Fortune 500 use RightFind, while over 900 life science companies utilize CCC products and services.

The post CCC Named to KMWorld 100 Companies That Matter in Knowledge Management for 2023 appeared first on Copyright Clearance Center.

Since 2007, CCC has partnered with Outsell, Inc., to conduct quantitative research into how copyrighted content is used in a variety of industries. We’ll be reporting on the insights from the 2023 Information Seeking & Consumption study on Wednesday, 1 February at 10:00 a.m. EST.

We know that the use of published content is critical to accelerating knowledge and powering innovation, yet the sharing of that information without first obtaining copyright permissions carries potential risk. We produce these surveys to help those responsible for copyright compliance, such as legal counsel and information/knowledge managers, see how knowledge workers access and share information. Here are a few highlights:

• The shift to hybrid and remote work has created new dynamics for information and content sharing. Our 2023 survey found that remote workers share more often and with more people than in 2020.
• Companies are discussing copyright policies more often than in the past, but employees’ behaviors and attitudes around sharing content don’t reflect that.
• Executives have the highest level of awareness about copyright policy, but their own sharing practices aren’t always aligned with those policies.

Join me and Ned May, Chief Operating Officer for Outsell, Inc., on Wednesday 1 February 2023 at 10:00 a.m. EST (16:00 CET) for a full review of the 2023 Information Seeking and Consumption study.

View our webcast preview or register today.

The post Information Seeking & Consumption Study Results to be Announced Next Wednesday on CCC Webcast appeared first on Copyright Clearance Center.

Increasingly, the content landscape is more complex; more content providers as well as a broader range of internal data management tools lead to further siloing of data and making it inaccessible to users within an organization. Data driven organizations need to support both internal and external content, making it accessible to users and enabling them to realize the investment made in this content.

Access to data is one part of the problem; findability is a second challenge that data driven organizations face. In this blog post, learn how Copyright Clearance Center (CCC) and SciBite have combined their expertise to deliver a FAIR data platform that offers full semantic search within RightFind Navigate. RightFind Navigate both streamlines the delivery and aggregation of content and leverages industry leading named entity recognition to enable full semantic search over aggregated content sets.

Bringing Content Together to Break Down Silos

As leaders in providing access to content, CCC developed RightFind Navigate to break down data silos and to streamline the delivery of information to users, whether that is scientific literature, global life science patents, or the latest information on drugs or ongoing clinical trials. RightFind provides access to the most comprehensive collection of scientific, medical and technical content, including over 5 million open access articles, in a copyright-compliant manner.

RightFind Navigate provides a unified view of both internal and external content sets, saves time and effort, and eliminates data silos that limit the accessibility and usability of this content by users. Through a machine learning (ML) backed search experience, users are able to personalize their search experience, helping them to find key insights quickly and efficiently and directly feeding into the development of the next generation of therapeutics. This search experience is further enhanced through the application of semantics, powered by the SciBite semantic platform.

Applying Semantics to Improve Findability and Usability of Content

SciBite are industry leaders in the enterprise-wide implementation of FAIR data principles. Through an award-winning semantic platform, SciBite uses hand curated and optimized ontologies (VOCabs) that contextualize and align data to the broader scientific community. These ontologies cover a broad range of concepts within the life sciences such as drugs, genes, proteins, combination therapies and medical devices. When combined with a named entity recognition and extraction tool (TERMite), these VOCabs are used to identify key concepts or entities within the data and assign an ID to these entities. A key to this tagging process is the ability to leverage the broad synonyms or different naming conventions that the VOCabs support, e.g. breast cancer, cancer of the breast, mammary tumour or breast tumour are all different names for the same thing. This means that independent of how the data was captured in the original text, it will be accurately identified. Once tagged as an entity and assigned an ID (for example MedDRA ID10006187 for breast cancer), users can leverage all of the synonyms associated with the ID for search and analytics. For the RightFind Navigate user, this means that independent of which search term they use, they will always return robust and inclusive search results. For example, whether the user searches for breast cancer or cancer of the breast, RightFind Navigate will know that these are equivalent and will return the same results, something that wouldn’t necessarily be the case if relying on string matching (keyword search). This improves the user experience and ensures that relevant content and insights are not missed.

How Does RightFind Navigate with Semantics Improve User Experience?

Data silos hamper access to data and limit the utility of internal and external content sets, as does the procurement of commercial data sources. Through RightFind Navigate, CCC provides a solution to streamline the delivery of published content and presents this alongside internal content and datasets. Combined with industry leading semantic search powered by the SciBite platform, RightFind Navigate enables this aggregated content to be effectively navigated and insights extracted. De-siloing this content not only saves time and improves user experience, it also maximizes ROI for organizations who invest heavily in both internal and external content. In addition, having a platform of organized and harmonized data unlocks a whole host of downstream applications that can take this ROI to another level, such as analytical dashboards and even predictive ML and AI models.

Keep Learning: In this white paper from CCC and SciBite, we highlight four practical applications for semantic enrichment across the drug development pipeline, enabling life sciences organizations to not only save time but increase the accuracy and efficiency of their processes.

Get in Touch: If you are interested in exploring how RightFind Navigate with semantic search powered by SciBite can support your internal and external content, then please reach out to your Copyright Clearance Center or SciBite account manager or get in touch via info@scibite.com or  solutions@copyright.com.

The post Leveraging Semantics for Effective Navigation of Scientific Content – A Copyright Clearance Center and SciBite Perspective appeared first on Copyright Clearance Center.

Most recently, CCC acquired the assets and technology of Deep SEARCH 9 (DS9). DS9 has employees and customers based in Europe. The DS9 team, including founder and CEO Klaus Kater and Director of Operations Dr. Sonja Müller, are now CCC employees.

DS9 is a knowledge management platform that leverages machine learning to help customers perform semantic search, tag content, and discover new insights. This powerful software makes it easy to collect and analyze information from a variety of internal and external sources. Several multinational life science and crop science companies use DS9 technology to provide semantic search solutions to support a wide range of use cases including: 

• Monitoring conferences to understand the latest research before it’s published 
• Tracking competitor news and trends to stay current in a rapidly changing market 
• Evaluating emerging biotechnology start-ups for potential investments and acquisitions
• Discovering licensing opportunities, grants, and clinical trials 

CCC will continue to support current customers and offer DS9 solutions, and over time will incorporate DS9 capabilities within CCC’s RightFind Suite. As we look ahead, we will engage DS9 and CCC RightFind customers in discussions about our product roadmap.To learn more about the RightFind Suite and CCC’s deep search capabilities contact us and visit our Deep Search Solutions page. 

The post CCC Expands Corporate Solutions Offering with New Technology appeared first on Copyright Clearance Center.

Meeting the daily evolution of consumer trends and setting the pace with disruptive innovation is the perennial challenge for food and other consumer package goods (CPG) companies. Big and small, new and old, the challenge is the same: how to discover key research, transform it into winning, breakthrough initiatives, and do it collaboratively and efficiently.

Join CCC, CJB and Associates, and a panel of leading R&D experts on 12 May 2022 from 12:00-1:00pm EDT for a discussion on the state of research practices in food and beverage organizations.

You can expect an engaging dialogue on how information best practices and technological accelerants can help streamline innovation, discovery, compliance, collaboration and responsiveness across R&D organizations.

What type of companies is this session for? All types, and not exclusively food and beverage. Research startups, ingredient companies, universities, Fortune food and beverage companies, and any company involved in research and development.

What roles is this session for? This session is for everyone. Research is a collaborative process with stakeholders across the organization: quality assurance, product developers, managers, researchers, legal, applied science, sales, marketing, and more.

I don’t do research in my role. Can I still come? Absolutely, and you might be surprised to learn how key research initiatives can support you in your role.

What kinds of information will the panel cover?

• How scientific research is used to support innovation in Food companies today
• Common pain points in using and managing scientific literature
• Best practices to vet the veracity of the research
• Tips for better managing and leveraging scientific literature to fuel innovation

Moderator: David Key, Director of Business Development, CJB and Associates

Panelists:

• Carlos Barroso, Founder & President, CJB and Associates
• Jeff George, SVP of Corporate R&D, Hain Celestial
• Amenah Ibrahim, Principle, AI R&D Project Management Services, LLC.

Learn more about if this session is right for you and register here.

In the meantime, you might also enjoy these related blogs on food innovation and R&D:

Food Companies in Crisis: What Happens and How to Prevent It

Populating Your Breakthrough Food Innovation Pipeline: 3 Types of Content You Might Be Missing

The post CCC to Host Panel of Food R&D Experts on 12 May appeared first on Copyright Clearance Center.

What exactly does a food crisis look like?

In 2002, a group of researchers at the University of Stockholm discovered that high acrylamide levels were present in cooked, starch-based foods like potato chips. After delivering their findings to the Swedish National Food Administration, the alarm was sounded. The news was devastating to snacks in European and Asian markets. Potato snack companies experienced falling stock prices, and in-store potato snack purchases in Sweden and bordering countries were reduced by over 50%. In the United States, the findings had a minimal effect initially. However, three years later in 2005, a lawsuit by the California attorney general was leveled at my company, Frito Lay, as well as a few other large snack companies. As a company with a sizable portion of their portfolio in snacks, and not wanting to risk a recall, this was not something we could wait to play out. We needed to get ahead of it and understand what was going on.

What Happens in a Crisis?

In the first 24 hours, companies, media, and regulators will all scramble to understand what the risk is and what is being done about it. The media will search for any fatalities or injuries that could be linked to the product in question. The regulatory agencies will be doing their own research to understand what threat there is to the public. They will also be in touch with the food companies for additional information with the implied threat of recalls and/or fines. The CEO will often work directly with internal teams such as the food safety head, research team, and PR director to understand and craft proactive narratives. They will want research studies and hard data to support their plan of action.

It is important that the companies be the first to respond to both the media and the regulatory bodies. They will need a narrative for the public, a more detailed hypothesis of the actual threat for regulators, a plan of action, and a preponderance of supporting research data. Having fast access to both internal and external research and the ability to quickly search and sort is essential.

After the threat to the consumer is assessed —and it is often not black and white—a plan of action will be mandated by the regulators or, more often, self-imposed by the companies. If the threat is great, there could be a recall, as happens several times a year with salmonella-tainted produce. A more likely scenario is that more research will be commissioned to further understand the danger and move to remedy it, which can take years and cost millions of dollars. In the case of Frito Lay and acrylamide, we agreed to a fine, and to reduce the levels of acrylamide below a certain threshold. Over the following year, this became a top priority, with Frito Lay going above and beyond the mandate with innovations to ensure consumer safety. While I am not sure how much Frito Lay ended up spending, similar companies were known to have spent tens of millions of dollars on this mitigation research.

Whether the threat ends up being real or perceived, companies will innovate around how to address the underlying issue. In some cases, like partially hydrogenated oil, companies had already been working on alternative shelf-life extension technology and the shift was relatively painless. In other cases, like with acrylamide, the research was not obvious, and it took many years for solutions like acrylamide-reducing yeast to hit bread and asparaginase for chip products.

How to React

Gather as much research as possible. Search broadly for every article and academic journal. Leave no stone unturned. Make sure you have a robust system in place by which you can access and license research from not only food and beverage sources, but adjacent medical and chemical industries as well. The ability to dig for similar articles by search term and tags is extremely important. Having the right content is only half the battle; being able to find it when you need it is the real challenge.

Do not focus your initial research on solving the problem. Your initial research should be aimed more at understanding the problem as fully as possible.  Consider these examples:

Cyclamate was a very useful artificial sweetener with wide international distribution and use before a late 1960s study caused the FDA to revoke its GRAS status for potentially causing cancer. All the research later proved there was no link.

Toxic shock syndrome caused P&G to withdraw their recently launched Rely tampons. Again, the data later showed there was no link.

In the early 2000s, there was a provocative study of aspartame on lab rats that suggested it might cause cancer. Although not as sudden as the acrylamide situation, there was no small concern among beverage companies as to their substitute sweetener drinks. However, additional research found that aspartame, outside of elephant-sized doses, is benign.

There are many other examples, but the point is that there is high urgency to get as much research on the issue in order to respond in an informative way to company leadership and outside regulatory bodies and influencers.

How to Prevent a Crisis in the First Place

The easy answer is: don’t miss anything! But how do you do that, or at least make the best effort you can? I recommend investing in the most robust search tools you can. No company wants anyone to get hurt, but they often don’t have the best content management systems or tools needed to understand all the cutting-edge innovations across industries. This must change. The cost to arm researchers, particularly in food safety, is paltry when compared to the cost of a food crisis. Comprehensive access to research might potentially prevent a crisis from happening. In addition, your food safety specialists will sleep much better and thank you for the peace of mind.

Make collaboration and the dissemination of research easy and compliant across your organization. Many hands make light work, and many eyes are more likely to catch something obscure. In addition, there is a strong argument that the innovation benefits of cross-organizational sharing, just by themselves, cover any associated costs. However, to my topic, the value of not missing something important is well worth the investment.

Hopefully, your company will never experience a food crisis. But, when it comes to safety, preparing for the worst and setting yourself up for success is the way to go. Invest in tools and technology that allow you to collaborate and work swiftly across your organization. Responding quickly with data and case studies will help your leadership understand the risk and make the best possible strategic decisions.

Related reading:

Optimizing Research to Drive Food Innovation and Organizational Success

Populating Your Breakthrough Food Innovation Pipeline: 3 Types of Content You Might Be Missing

The post Food Companies in Crisis: What Happens and How to Prevent It appeared first on Copyright Clearance Center.

As an example, when my former research team was looking for a way to reduce sodium in a topical application, we started with a hypothesis that a more surface-to-mass ratio would increase salt perception. Therefore, we assumed a nano-sized particle would be ideal. Our search through both food academic journals and adjacent industry academic medicals led us to the ETH Zurich Department of Chemical Engineering where they were working on Osteoporosis solutions by creating nano-sized particles of calcium to fill in the areas of bones affected. They had discovered a flame nanoparticlization process but used table salt for experimenting as it was safer. Indeed, from this non-obvious connection, the research team at ETH Zurich was able to create nano-sized particles of salt, but the particles were so small they quickly coalesced. The team in Zurich guessed as much and suggested using ceramic milling to create micron-sized particles which were an order of magnitude smaller than what was available from the typical salt suppliers. As a result of discovering this information, we were able lower our sodium application by as much as 25%.

You never know where the next big discovery will come from, so it is important to cast a wide net of the content you and your team collaborate on for leads. Here are three content areas you might consider when searching for leads on your next breakthrough innovation:

Medical Research

There were numerous studies in the medical community around hypertension and high blood pressure before consumers demanded lower sodium in their soups and snacks. Eventually the ingredient and process technology caught up, but the industry could have responded much faster had we seen the study trends in the medical community earlier. The pharmaceutical industry unlocked time-release flavor delivery for use with bad tasting medicines. It eventually was reapplied to the food industry and revolutionized our ability to add bad tasting supplements to food without releasing their flavors in the mouth.

As many companies turn their attention to what is beyond-better-for-you trends, it seems likely products will be more solution-oriented and further blur the line between food and medicine. Do you have leaky-gut and like cookies? Great, here are some treats with fiber and prebiotics. Are you feeling depressed and like snacks? No problem, here are some cruciferous vegetable chips optimized for antioxidants. Cross-referencing research into medical repositories like PubMed and Cochrane Library, or general medical academic journals are great ways to get out-of-the-box idea generation.

Climate and Sustainability Science

At the most recent Natural Products Expo West, “plant-based” was a clear show trend. It’s no secret that meat analog firms like Impossible and Beyond have exploded in popularity in the past few years, and for good reason: plant-based and fermentation-driven protein alternatives are now in high demand among omnivores because they are more sustainable.

Consumer demand for sustainably sourced products begs the question, “what else could be made more sustainable?” This could be a practical question: “how can bottlenecks in pea protein production be averted through more efficient and sustainable processing?” Or it might also be something more obscure like “can climate-adjusted residential insulation cooling be repurposed to optimize cold chain in a meaningful way?” Cross-referencing your research with something untraditional to food like environmental academic journals could lead to a niche research discovery that revolutionizes the way pea protein is farmed and processed. You never know what you will find!

Your Company’s Content Archives

Smart companies understand the generative power of institutional learnings, and that many efficacious ideas are simply too early or get killed prematurely for political or budget reasons. Building a content system that makes them easy to reference and recall is challenging and often overlooked.

Mid- and large-sized food and ingredient companies generate thousands of reports each year. Many are chock full of ideas and experiment results. A content system with relevant tags can cross-reference the terms and themes of contemporary academic papers with thousands of internally archived reports and experiments. This is one of the best ways to find fertile ground for breakthrough innovation (as well as avoiding duplication). Global access opens up even more opportunity to lift and adapt regional successes and breakthroughs.

The pace of technological change is rapid. R&D is not known for having a lot of free time to track down every new little concept. Teams must be practical and efficient in the innovation journey. For development passion to marry with the practical concerns of meeting everyday consumer needs, it will require smart tools and smart research collaboration.

Related Reading:

Optimizing Research to Drive Food Innovation and Organizational Success

Food Companies in Crisis: What Happens and How to Prevent It

The post Populating Your Breakthrough Food Innovation Pipeline: 3 Types of Content You Might Be Missing appeared first on Copyright Clearance Center.

Yet today, across Ukraine, libraries are places for refuge from and resistance against the Russian invasion.

“We’ve seen public libraries that have turned into shelters, including some at the cities that are being shelled. We’ve seen photographs of libraries running children’s sessions, activities, play sessions for very small children in really challenging circumstances,” says Nick Poole, CEO of CILIP, the UK Library and Information Association.

Click below to listen to the latest episode of the Velocity of Content podcast

Wartime Role for Ukraine Libraries

“And we’ve seen the Ukrainian library community mobilize to combat disinformation,” he tells me. “There’s obviously a lot of state-sponsored fake news and disinformation flying around. Librarians there are right in the middle of it all, helping people tell fact from fiction.”

In a recent essay for The Scotsman newspaper, Poole shared a series of moving exchanges with Ukrainian librarians. His besieged colleagues, he says, fear attacks on libraries not simply for the damage done to books and buildings.

“Ukraine has a literary tradition, a cultural identity, a strong and proud tradition of language and creativity,” Poole says. “I think the real fear is that that’s going to be erased as Russian forces make their way through the country.”

The Ukrainian Library Association represents 57,000 librarians and more than 33,000 libraries across Ukraine. Photos and posts to the ULA Facebook page continue to provide regular updates on the new wartime role Ukrainian librarians.

The post Wartime Role for Ukraine Libraries appeared first on Copyright Clearance Center.

We hear time and again, whether working with growing startups or established global organizations, individual functions of R&D very often operate in siloes. This applies across industries, not limited to pharmaceuticals, biotech, chemicals, food, and energy. The result is often duplicated efforts, wasted time and resources, and slow or chaotic responses to urgent situations where access to scientific information and data is crucial (think: adverse medical events, environmental disasters, product recalls, etc.)

Removing these barriers to information is one of the problems we aim to solve with our licensing and content management solutions. Here’s a quick look at some of the ways our customers use RightFind to facilitate copyright-compliant collaboration across the R&D pipeline.

Discovery & Idea Generation

Think about the early days of the pandemic when researchers set out to find treatments and vaccines to fight the disease caused by the SARS-CoV-2 virus. They weren’t starting from scratch. In fact, by April 2020 there were already 39,000 articles in our Covid Collection within RightFind.

Even when coming up with a brand-new product, almost all R&D projects involve some level of assessment of the current research landscape. In RightFind, reseachers and investigators can analyze previously published studies and create reviews of articles pertaining to a topic, such as a specific disease, chemical compound, or ingredient.

Regulatory

Scientific literature plays a critical role in the regulatory submission cycle. Researchers must find the right content and be able to cite it in formats required by different regulatory bodies. For example, regulatory affairs groups often work closely with other departments within RightFind to centralize and organize published literature, cite them, and prepare documentation for the regulatory team to review and submit patent submissions and filings to the appropriate agencies.

The ability to easily confirm copyright permissions is also an important piece of the puzzle. As one information specialist at a global consumer goods company put it: “For most of our workflows, we end up needing multiple layers of permissions, and users don’t always know what permissions they’ll need at the start of a project. Sometimes an article will start off being reviewed by a single scientist, but if it’s identified as an important innovation or safety alert then it will be shared across the business and might eventually be provided to healthcare professionals or even regulatory bodies. Our workflows involve us going back to RightFind for an additional permission, more often than not.”

Patent Validity

For information professionals, excluding patent searches from a literature review could mean missing an entire corpus of information that will never appear in a traditional biomedical databases. (You can read more on the benefits of exploring patents here.)

In addition to advanced patent exploration searching, patent attorneys and others who typically perform a review of non-patent literature for invalidity surveys often save and store copies of articles or other supporting documentation identified as being relevant during their reviews within RightFind.

Safety

Scientific literature is one of the most significant sources of information to monitor the safety profile and the risk-benefit balance of products, particularly in relation to detecting new or emerging safety signals or issues. Reviewing all known literature during the discovery and idea generation phase for a product helps to surface any potential issues, ultimately helping to prevent a costly recall. Once a product has launched, having that literature available on the fly is critical if a regulatory body were to issue a safety warning.

Within RightFind, colleagues can monitor, review, and automate the literature review process to rapidly identify safety issues like adverse events, get quick access to content, and satisfy regulatory requirements.

Medical Affairs

At pharmaceutical companies, the role of medical affairs has moved from simply disseminating information to providing market-based strategic input to drug development and portfolio management.

Medical affairs departments have an opportunity to become the voice of a company to the outside world, including speaking to payers, patients, physicians, regulators and government agencies. In this sense, facilitating collaboration can mean organizing access to the latest approved literature to quickly answer client inquiries. Because this job function is often involved in all aspects of a drug’s life cycle, so the collaborative tools within RightFind for commenting, annotating, and reviewing documents across departments is particularly useful.

Competitive Intelligence

Missed information can be extremely costly, particularly for competitive intelligence teams who are responsible for understanding the landscape that informs their company’s go-to-market strategy. Competitive intelligence teams use RightFind to create libraries for approved team members where all information related to a specific product, therapeutic, or topic of research can not only be accessed, but also annotated and highlighted. Automated alerts can also be set up to help individuals or teams receive the most relevant information about their focus area without having to search for it.

Marketing & Communications

Claims made in a company’s promotional materials need to be substantiated. With full-text copies of all supporting materials living in RightFind, marketers can easily access set up alerts around a product to be informed of new mentions of a product, store marketing materials and published literature related to a specific product.

Fuel Innovation Across the Enterprise

A scientific literature and data strategy that’s designed to fit the needs of employees across the enterprise sets up an organization for better collaboration, minimized risk of copyright infringement, and ultimately the fuel needed to drive innovation and new discoveries.

Interested in seeing real examples of how R&D teams use RightFind and our copyright licensing solutions? Check out our case studies featuring customers in life sciences, biotech, chemical, consumer goods, and more. Click here to contact us about content management and licensing solutions for your organization.

The post Utilizing RightFind Across the R&D Pipeline appeared first on Copyright Clearance Center.

But whether in early research, drug safety, or market access, the underlying knowledge challenges that arise when bringing a drug through the development pipeline are similar: an ever-expanding body of knowledge in the face of limited time and resources to synthesize, draw insights, and ultimately make decisions.

Individual decisions made by researchers, scientists and project leaders operating on the frontlines in turn inform key decisions at the enterprise level. From which therapeutic programs to pursue, to how to optimize the portfolio mix – the effects of the individual ‘micro-decisions’ trickle-up in a non-linear way to impact strategic choices and business-level outcomes.

At Causaly, we focus on improving how users think and, therefore, decide based on critical evidence. Individual decisions like identifying a promising target or assessing the competitive landscape can create massive opportunities and steer the course of the outcome.

Knowledge Graphs for Target Identification

These non-linear impacts are clearly illustrated in early discovery, when researchers begin a process to identify, validate and select targets related to a given indication or a broader disease area.

In our experience working with multiple discovery teams at different pharma customers, this process is prone to scientific bias and carries a high chance of missing promising targets due to the overwhelming amount of biological evidence, coupled with a significant degree of noise in research literature.

Take as an example Systemic Lupus Erythematosus (SLE), an autoimmune disease for which there is currently no cure. There is an excess of 77,000 articles on SLE in PubMed alone – the human effort required to screen for relevance, shortlist, and eventually read, immediately limits the scope of discovery and biases the direction that the target-selection project could go.

With Causaly, it’s possible to instantly machine read the same literature and surface a list of c.2000 proteins and genes associated with the pathophysiological mechanisms of SLE, prioritized by the strength of the underlying evidence. The ability to query the full corpus of available research literature at scale in this way expands the discovery horizon and saves the researcher valuable time in the process. Most importantly, it makes it more likely that innovative targets that would not have been otherwise identified are found and pursued.

At the business level, a slight innovation in a knowledge workflow can fundamentally shift how further investigation is set up downstream in a 10-year-long pipeline that exists from discovery to commercialization.

• Related reading: How Can AI Boost Research Productivity in Literature Search and Drug Safety?
• To learn more about the CCC-Causaly partnership, contact our solutions team at CCC.
• To learn more about Causaly and how it could unlock value in your organization, please contact contact@causaly.com.

¹For drugs entering clinical development, as estimated by Joseph A. DiMasi, Henry G. Grabowski, and Ronald W. Hansen, “Innovation in the pharmaceutical industry: New estimates of R&D costs,” Journal of Health Economics, 2016, Volume 47, pp. 20–33

The post AI for Knowledge Workflows: From Incremental Innovations to Fundamental Business Value appeared first on Copyright Clearance Center.